CDDO-EA

SKU: orb1309853

Description

CDDO-EA (CDDO ethyl amide) is a potent synthetic triterpenoid that activates the Nrf2 signaling pathway. It is widely used in research to study oxidative stress, inflammation, and cytoprotection in both cellular and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 932730-51-3
• MW: 518.73
• Purity: 99.66%
• Formula: C₃₃H₄₆N₂O₃
• SMILES: [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)C(=O)NCC
• Target: Nrf2
• Solubility: DMSO:28 mg/mL (53.98 mM)

Bioactivity

• In Vivo:
  CDDO-EA-treated G93A mice live significantly longer than the control. CDDO-EA increases the life-span from 124.05 days to 144.72 days (16.6%). In CDDO-EA-treated G93A mice, the age of death is 141.4 days and the duration from the age of onset to the age of death is 57.6 days. The age of death from the onset is prolonged by 17.5 days (43%) .
• In Vitro:
  In a cell culture model of ALS, CDDO-EA potently activates Nrf2/ARE . CDDO-EA induces apoptosis in A549 lung cancer cells and induces heme oxygenase-1. CDDO-EA is 7-fold more potent than CDDO as a suppressor of the ability of IFN-γ to induce iNOS in RAW264.7 macrophage-like cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDDO ethyl Amide, CDDO ethyl amide, CDDO-EA, Nrf2, Nrf2/ARE, TP 319, TP319, TP-319, RTA 405, RTA405, RTA-405

Compound Identifiers

PubChem CID

44159258