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CD91 Antibody / LRP1 / A2MR

Catalog Number: orb1825776

DispatchUsually dispatched within 5-10 working days
$ 410.00
Catalog Numberorb1825776
CategoryAntibodies
DescriptionMembers of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and Alpha-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including Alpha-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.
Species/HostMouse
ClonalityMonoclonal
Clone NumberLRP1/6784
Tested applicationsIHC-P
ReactivityHuman
IsotypeMouse IgG1, kappa
ImmunogenA recombinant fragment of human protein was used as the immunogen for the Alpha 2 macroglobulin receptor antibody.
Antibody TypePrimary Antibody
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
ConjugationUnconjugated
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis Alpha 2 macroglobulin receptor antibody is available for research use only.
UniProt IDQ07954
StorageAliquot the Alpha 2 macroglobulin receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
NoteFor research use only
Expiration Date12 months from date of receipt.
CD91 Antibody / LRP1 / A2MR

IHC staining of FFPE human lung tissue with Alpha 2 macroglobulin receptor antibody (clone LRP1/6784) Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

  • CD91 Antibody / LRP1 / A2MR [orb1825673]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    100 μg
  • CD91 Antibody / LRP1 / A2MR [orb1825674]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    20 μg
  • CD91 Antibody / LRP1 / A2MR [orb1825675]

    IHC-P

    Human

    Rabbit

    Recombinant

    Unconjugated

    100 μg
  • CD91 Antibody / LRP1 / A2MR [orb1825679]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg
  • CD91 Antibody / LRP1 / A2MR [orb1825680]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    20 μg