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    CD45 Antibody (Leukocyte marker)

    Catalog Number: orb1824297

    DispatchUsually dispatched within 5-10 working days
    $ 405.00
    Catalog Numberorb1824297
    CategoryAntibodies
    DescriptionCD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
    Species/HostMouse
    ClonalityMonoclonal
    Clone NumberPTPRC/6780
    Tested applicationsIHC-P
    ReactivityHuman
    IsotypeMouse IgG1, kappa
    ImmunogenRecombinant full-length human PTPRC protein was used as the immunogen for the CD45 antibody.
    Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
    ConjugationUnconjugated
    Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
    Hazard InformationThis CD45 antibody is available for research use only.
    UniProt IDP08575
    StorageAliquot the CD45 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
    NoteFor research use only
    Expiration Date12 months from date of receipt.
    CD45 Antibody (Leukocyte marker)

    IHC staining of FFPE human tonsil tissue with CD45 antibody (clone PTPRC/6780). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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      FACS,  IF,  IHC-P

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      FACS,  IF,  IHC-P

      Human

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      Monoclonal

      Unconjugated

      100 μg, 20 μg
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