Cbz-NH-PEG5-CH2COOH

SKU: orb1307470

Description

Cbz-NH-PEG5-CH2COOH is a heterobifunctional PROTAC linker featuring a carbobenzyloxy-protected amine and a terminal carboxylic acid, connected by a flexible pentafethylene glycol) spacer. This water-soluble linker is widely used in chemical biology for constructing proteolysis-targeting chimeras (PROTACs) for both in vitro and in vivo degradation studies.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1449390-66-2
• MW: 429.46
• Purity: 98.33% (May vary between batches)
• Formula: C₂₀H₃₁NO₉
• SMILES: C(OC(NCCOCCOCCOCCOCCOCC(O)=O)=O)C1=CC=CC=C1
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs, which consist of two distinct ligands connected by a linker—one binding an E3 ubiquitin ligase and the other targeting a specific protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PEGs, PROTAC Linkers, PROTAC Linker, PROTACLinker, inhibit, Inhibitor, Cbz NH PEG5 CH2COOH, CbzNHPEG5CH2COOH, Cbz-NH-PEG-5-CH2COOH, Cbz-NH-PEG5-CH2COOH

Compound Identifiers

PubChem CID

118986708