Carbamazepine 10,11-epoxide

SKU: orb1940320

Description

Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells expressing CYP3A4 or CYP2C8, respectively.Carbamazepine 10,11-epoxide has anticonvulsant activity against maximal electroshock-induced seizures in mice.2It has been found in wastewater effluent.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	36507-30-9
MW	252.273
Purity	>98% (HPLC)
Formula	C₁₅H₁₂N₂O₂
SMILES	NC(=O)N1c2ccccc2C2OC2c2ccccc12
Target	PDE4\|PDE4B1\|PDE4D7
Solubility	In Vitro: DMSO : 125 mg/mL (495.50 mM)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

PDE4|PDE4B1|PDE4D7

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