Caffeic Acid

SKU: orb1304995

Description

Caffeic Acid

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 331-39-5
• MW: 180.16
• Purity: 98.96%
• Formula: C₉H₈O₄
• SMILES: C(=CC(O)=O)C1=CC(O)=C(O)C=C1
• Target: TRP/TRPV Channel,Lipoxygenase,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (27.75 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:250 mg/mL (1387.66 mM)

Bioactivity

• Target IC50:
  Canine distemper virus:23.3 μg/mL (at 1h post infection)|renin:5704 µM|DNA methylation:3.0 μM
• In Vivo:
  METHODS: To study the anti-pruritus effect of Caffeic Acid, Caffeic Acid (500 mg/kg) was orally administered to mice induced by histamine and chloroquine. RESULTS: Caffeic acid pretreated mice showed significantly less histamine-induced scratching and chloroquine-induced scratching.
• In Vitro:
  METHODS: Human A549 cells were treated with Caffeic Acid for 48 h, and cell growth inhibition was measured using MTT assay. RESULTS: Caffeic Acid inhibited the growth of A549 cells (IC50=0.7 mM). METHODS: Human AGS and HCT-116 cells were treated with Caffeic Acid for 96 hours, and cell growth inhibition was detected using MTT assay. RESULTS: Caffeic Acid inhibited the growth of AGS (IC50=129 μM) and HCT-116 (IC50=29.73 μM) cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Caffeic Acid, 5-Lipoxygenase, LOX, Lipoxygenase, Inhibitor, inhibit, Endogenous Metabolite, EndogenousMetabolite, hTRPA1, Transient receptor potential channels, TRPChannel, TRPV Channel, TRPVChannel, TRP Channel

Compound Identifiers

PubChem CID

2518