BW 755C

SKU: orb1306108

Description

BW 755C is a dual-action small molecule inhibitor that simultaneously blocks both the 5-lipoxygenase (5-LO) and cyclooxygenase (COX) enzymatic pathways. It is widely used in pharmacological research to study eicosanoid biosynthesis and inflammation in both cellular (in vitro) and animal (in vivo) experimental models.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 66000-40-6
• MW: 229.2
• Purity: 96.52% (May vary between batches)
• Formula: C₁₀H₁₀F₃N₃
• SMILES: C(F)(F)(F)C=1C=C(C=CC1)N2N=C(N)CC2
• Target: COX,Lipoxygenase
• Solubility: Ethanol:20 mg/mL (87.26 mM);DMSO:25 mg/mL (109.08 mM)

Bioactivity

• Target IC50:
  COX-1: 0.65 μg/ml|COX-2: 1.2 μg/ml|5-LOX: 0.75 μM
• In Vitro:
  BW 755C is approximately equipotent inhibitors of COX-1 and COX-2 in intact cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-LOX, BW 755C

Compound Identifiers

PubChem CID

47795