Butylphthalide

SKU: orb1302350

Description

3-Butylphthalide is a small molecule originally isolated from celery seeds (Apium graveolens). It is widely used in research for its neuroprotective properties, particularly in models of cerebral ischemia, with studies conducted both in vitro and in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 6066-49-5
• MW: 190.24
• Purity: 98.34% (May vary between batches)
• Formula: C₁₂H₁₄O₂
• SMILES: CCCCC1OC(=O)c2ccccc12
• Target: p38 MAPK,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.51 mM);DMSO:250 mg/mL (1314.13 mM)

Bioactivity

• In Vivo:
  Butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits . Intragastric NBP administration to 4-month-old SAMP8 mice for 2 months significantly improved spatial learning and memory ability. Moreover, the loss of choline acetyltransferase (ChAT)-positive neurons in the medial septal nucleus and the vertical limb of the diagonal band in SAMP8 mice was slowed down, as was the decline in the protein and mRNA expression of ChAT in the hippocampus, cerebral cortex, and forebrain .

Storage & Handling

• Storage: keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-Butylphthalide, 3-n-Butylphathlide, 3-n-Butylphthalide, Butylphthalide, inhibit, Inhibitor

Compound Identifiers

PubChem CID

61361