Busulfan

SKU: orb1224664

Description

Busulfan is a bifunctional alkylating agent.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 55-98-1
• MW: 246.3
• Purity: >98% (HPLC)
• Formula: C₆H₁₄O₆S₂
• SMILES: CS(=O)(OCCCCOS(C)(=O)=O)=O
• Target: DNA Alkylator
• Solubility: DMSO: 49 mg/mL (198.94 mM)

Bioactivity

• In Vivo:
  Animal model: ICR male mice ranging in age from 8 to 12 weeks (30-40 g). Dosage: 40 mg/kg (in sesame oil). Administration: IP; single dose. Result: Increased apoptosis and decreased the testis weight in mice. Exhibited higher level of pRB expression, inhibited Rb phosphorylation and PCNA expression compared to the control.
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• In Vitro:
  Western blot analysis. Cell line: WI38 cells. Concentration: 120 μM. Incubation time: 24 hours. Result: Incited a moderate p53 activation, but strong Erk, p38, and JNK phosphorylation, in a time-dependent manner. Elicited an immediate up-regulation of p21 expression, which subsided by day 11.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Busulphan | Mielosan | Milecitan | Myeloleukon | Mylecytan | Myleran | NCI C01592 | NSC 750

Quick Database Links

Gene Symbol

DNA Alkylator