Buntanetap

SKU: orb1706426

Description

Buntanetap ((+)-Phenserine) is an orally bioavailable small molecule inhibitor targeting toxic proteins implicated in neurodegeneration. It is utilized in preclinical research for Alzheimer's and Parkinson's disease, with studies demonstrating its effects in reducing amyloid-β and tau pathology in both cellular and animal models.

Research Area

Neuroscience

Key Properties

• CAS Number: 116839-68-0
• MW: 337.42
• Formula: C₂₀H₂₃N₃O₂
• SMILES: C[C@@]12C=3C(N(C)[C@@]1(N(C)CC2)[H])=CC=C(OC(NC4=CC=CC=C4)=O)C3
• Target: Cholinesterase (ChE)|||Beta Amyloid|||Huntingtin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.82 mM);DMSO:200 mg/mL (592.73 mM)

Bioactivity

• Target IC50:
  AChE:45.3 μM|AChE:（ki）48 μM
• In Vitro:
  Buntanetap (1-25 μM, 24 h) significantly decreased the expression of APP, αSYN and HTT in SH-SY5Y cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BetaAmyloid, Beta Amyloid, cholinesterase, ANV S401, ANVS401, Amyloid-β, b Amyloid, bAmyloid, AChE., AChE, (+) Phenserine, (+)Phenserine, (+)-Phenserine, Huntingtin, Phenserine, β Amyloid, α-synuclein, βAmyloid

Compound Identifiers

PubChem CID

11249342