Bucolome

SKU: orb1710193

Description

Bucolome (Paramidine) is a small molecule inhibitor of the cytochrome P450 2C9 enzyme. It exhibits dual uricosuric and anti-inflammatory properties, making it a tool for research in pharmacology, enzymology, and metabolic studies, including in vitro CYP inhibition assays and in vivo models of hyperuricemia and inflammation.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 841-73-6
• MW: 266.34
• Purity: 99.83% (May vary between batches)
• Formula: C₁₄H₂₂N₂O₃
• SMILES: O=C1N(C(=O)NC(=O)C1CCCC)C2CCCCC2
• Target: Immunology/Inflammation related,Cytochromes P450
• Solubility: DMSO:50 mg/mL (187.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.51 mM)

Bioactivity

• In Vitro:
  In studies with recombinant human cytochrome P-450 2C9 and liver microsomes, Bucolome is a potent mixed-type inhibitor for (S)-warfarin 7-hydroxylation, with Ki of 8.2 and 20.2 microM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP2C9, 5-Butyl-1-cyclohexylbarbituric acid, Bucolom, Bucolome, Bucolomum, Paramidin, Paramidine, Immunology related, Immunologyrelated, Inflammationrelated, inflammation, Inflammation related

Compound Identifiers

PubChem CID

2461