BS3 Crosslinker disodium

SKU: orb1308513

Description

BS3 Crosslinker disodium is a non-cleavable, homobifunctional NHS-ester linker used in the synthesis of antibody-drug conjugates (ADCs). It enables stable covalent conjugation between antibodies and cytotoxic payloads, facilitating targeted drug delivery research in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 127634-19-9
• MW: 572.43
• Purity: 99.80% (May vary between batches)
• Formula: C₁₆H₁₈N₂Na₂O₁₄S₂
• SMILES: O=S(C(C1)C(N(OC(CCCCCCC(ON2C(C(S(=O)([O-])=O)CC2=O)=O)=O)=O)C1=O)=O)([O-])=O.[Na+].[Na+]
• Target: ADC Linker,PROTAC Linker
• Solubility: DMSO:125 mg/mL (218.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.99 mM)

Bioactivity

• In Vitro:
  ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Linker, ADC Linkers, ADCLinker, BS3 Crosslinker, BS3 Crosslinker disodium, BS-3 Crosslinker disodium, Antibody-drug conjugates linkers, Inhibitor, Non-cleavable, inhibit

Compound Identifiers

PubChem CID

6097991