Bruceantinol

SKU: orb1297439

Description

Bruceantinol is a bioactive small molecule with demonstrated antiviral activity against pepper mottle virus and potent antibabesial effects, exhibiting an IC50 of 12 ng/mL against Babesia gibsoni in vitro. Its properties make it a candidate for research in plant virology and veterinary parasitology, including potential in vivo studies for babesiosis.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 53729-52-5
• MW: 606.61
• Purity: 99.52% (May vary between batches)
• Formula: C₃₀H₃₈O₁₃
• SMILES: [H][C@]12[C@@H](OC(=O)\C=C(/C)C(C)(C)OC(C)=O)C(=O)O[C@]3([H])C[C@@]4([H])C(C)=C(O)C(=O)C[C@]4(C)[C@@]4([H])[C@@H](O)[C@H](O)[C@]1(OC[C@@]234)C(=O)OC
• Target: Apoptosis,Necroptosis,Serine/threonin kinase,c-Myc,Anti-infection,STAT,Survivin,Bcl-2 Family,CDK
• Solubility: DMSO:55 mg/mL (90.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.65 mM)

Bioactivity

• In Vitro:
  A green fluorescent protein (GFP)-tagged pepper mottle virus (PepMoV) based leaf-disc method and systemic host method were developed to identify antiviral agents. Preliminary experiments using a PepMoV-GFP based leaf-disc method led to the isolation of five quassinoids, including brusatol (1), bruceantin (2), brucein A (3), Bruceantinol (4), and brucein B (5), from the CH3OH extract of Brucea javanica

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Anti-infection, Antiinfection, Antifection, Bruceantinol

Compound Identifiers

PubChem CID

5281305