Brr2-IN-3

SKU: orb1306030

Description

Brr2-IN-3 (C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. This compound serves as a research tool for investigating Brr2's role in pre-mRNA splicing and its implication in autosomal-dominant retinitis pigmentosa, enabling mechanistic studies in vitro.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2104030-82-0
• MW: 444.51
• Purity: 99.26% (May vary between batches)
• Formula: C₂₄H₂₀N₄O₃S
• SMILES: O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1
• Target: Others
• Solubility: DMSO:27.5 mg/mL (61.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.5 mM)

Bioactivity

• Target IC50:
  BRR2:1.3 μM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, helicase, allosteric, Brr2 IN 3, Brr2 Inhibitor 9, Brr2 Inhibitor C9, Brr2IN3, Brr-2-IN-3, Brr2-IN-3, dose-dependent, potent, selective, spliceosomal RNA helicase Brr2, targeting

Compound Identifiers

PubChem CID

132585219