Bromo-PEG2-CH2-Boc

SKU: orb1308519

Description

Bromo-PEG2-CH2-Boc is a bifunctional PROTAC linker featuring a bromoalkyl handle for conjugation and a Boc-protected amine. This PEG-based spacer is utilized in constructing proteolysis-targeting chimeras for both in vitro and in vivo degradation studies, facilitating the exploration of targeted protein degradation as a therapeutic strategy.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1807518-63-3
• MW: 283.16
• Purity: ≥98% (May vary between batches)
• Formula: C₁₀H₁₉BrO₄
• SMILES: CC(C)(C)OC(=O)COCCOCCBr
• Target: PROTAC Linker
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  PROTACs consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bromo PEG2 CH2 Boc, BromoPEG2CH2Boc, Bromo-PEG-2-CH2-Boc, Bromo-PEG2-CH2-Boc, Alkyl/ether, Inhibitor, inhibit, PROTAC Linker, PROTACLinker, PROTAC Linkers, PEGs

Compound Identifiers

PubChem CID

77078163