BRD73954

SKU: orb1300784

Description

BRD73954

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1440209-96-0
• MW: 284.31
• Purity: 99.42%
• Formula: C₁₆H₁₆N₂O₃
• SMILES: C(NCCC1=CC=CC=C1)(=O)C2=CC(C(NO)=O)=CC=C2
• Target: HDAC
• Solubility: DMSO:16.67 mg/mL (58.63 mM);Ethanol:5.7 mg/mL (20.05 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.03 mM)

Bioactivity

• Target IC50:
  HDAC2:9 μM|HDAC6:36 nM|HDAC8:120 nM
• In Vitro:
  As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23 μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

α-tubulin acetylation, Ac-Tubulin, BRD 73954, BRD73954, BRD-73954, HeLa cells, HDAC6, HDAC8, HDAC4, HDAC2, HDAC, Histone deacetylases, H3 acetylation, Inhibitor, inhibit

Compound Identifiers

PubChem CID

71680913