BRD6688

SKU: orb1704987

Description

BRD6688

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1404562-17-9
• MW: 282.34
• Purity: 97.53% (May vary between batches)
• Formula: C₁₆H₁₈N₄O
• SMILES: Nc1ccc(cc1NC(=O)N1CCCC1)-c1ccncc1
• Target: HDAC
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.08 mM);dimethyl formamide:30 mg/mL (106.25 mM);Ethanol:≤2 mg/mL;DMSO:50 mg/mL (177.09 mM)

Bioactivity

• Target IC50:
  HDAC1:21 nM |HDAC3:11.48 μM|HDAC2:100 nM
• In Vivo:
  Mouse in-vivo study showed that BRD6688 was able to increase the histone acetylation (H4K12 and H3K9) in hippocampal CA1 neurons of CK-p25 mice. Moreove, the increased histone acetylation in brain served as a surrogate pharmacodynamic marker of HDAC engagement and was consistent with previously observed brain pharmacokinetic properties. In addition, BRD6688 rescued the cognitive deficits in CK-p25 mice, a model of neurodegeneration, in a Pavlovian fear conditioning behavioral assay.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD-6688, BRD6688, BRD 6688, inhibit, Histone deacetylases, HDAC2, HDAC1, HDAC3, HDAC, Inhibitor

Compound Identifiers

PubChem CID

66575862