BRD4884

SKU: orb1703662

Description

BRD4884 is a potent and selective inhibitor of HDAC1, HDAC2, and HDAC3. It is a valuable research tool for investigating epigenetic mechanisms in models of neurological disorders, including in vitro cellular assays and in vivo animal studies.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1404559-91-6
• MW: 314.35
• Formula: C₁₈H₁₉FN₂O₂
• SMILES: N(C(=O)C1CCOCC1)C=2C=C(C=CC2N)C3=CC=C(F)C=C3
• Target: Others
• Solubility: DMSO:20 mg/mL (63.62 mM)

Bioactivity

• Target IC50:
  HDAC3:1.09 μM|HDAC1:29 nM|HDAC2:62 nM
• In Vivo:
  BRD4884 has a half-life of 0.9 hours in mice and has good brain permeability. BRD4884 (10 and 1 mg/kg, intraperitoneal injection) salvaged memory deficits associated with P25-induced neurodegeneration in situational fear conditioning.
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• In Vitro:
  BRD4884 is a potent HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively. BRD4884 (10 μM for 24 hours) increased acetylation of histone H4K12 and H3K9 in mouse forebrain primary neuron cultures.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD4884, BRD-4884, BRD 4884

Compound Identifiers

PubChem CID

71465631