BRD0639

SKU: orb1298180

Description

BRD0639

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2760881-74-9
• MW: 475.95
• Purity: 99.46% (May vary between batches)
• Formula: C₂₁H₂₂ClN₅O₄S
• SMILES: S(NCCC1=CC=CC=N1)(=O)(=O)C2=CC(NC([C@H](C)N3C(=O)C=C(Cl)C=N3)=O)=CC=C2C
• Target: Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.2 mM);DMSO:60 mg/mL (126.06 mM)

Bioactivity

• In Vitro:
  BRD0639, a pioneering PBM-competitive small molecule, facilitates the research of PBM-dependent PRMT5 activities and aids in developing specific PRMT5 inhibitors. It effectively binds to the cellular target, efficiently inhibiting the interaction between full-length PRMT5 and RIOK1 proteins with IC50 values of 7.5 uM and 16 uM in permeabilized and living cells, respectively. Moreover, BRD0639 decreases SDMA levels in proteins impacted by genetic alterations of the PRMT5 binding motif (PBM) site .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histone Methyltransferase, HistoneMethyltransferase, BRD 0639, BRD0639, BRD-0639, PRMT5

Compound Identifiers

PubChem CID

156621384