BRD 9757

SKU: orb1702478

Description

BRD 9757

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1423058-85-8
• MW: 127.14
• Purity: 99.69% (May vary between batches)
• Formula: C₆H₉NO₂
• SMILES: C(NO)(=O)C=1CCCC1
• Target: HDAC
• Solubility: DMSO:< 1.27 mg/mL (10 mM, insoluble or slightly soluble)

Bioactivity

• Target IC50:
  HDAC4:21.80 μM|HDAC1:0.638 μM|HDAC9:>33.33 μM|HDAC5:18.32 μM|HDAC7:12.61 μM|HDAC2:1.79 μM|HDAC8:1.09 μM|HDAC6:0.03 μM|HDAC3:0.694 μM
• In Vitro:
  The IC50s are 0.638 μM, 1.79 μM, 0.694 μM, 21.80 μM, 18.32 μM, 12.61 μM, 1.09 μM and >33.33 μM, respectively for HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8 and HDAC9. BRD 9757 (10-30 μM) selectively increases Ac-tubulin levels without affecting histone acetylation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD 9757, BRD9757, BRD-9757, HDAC6, N-Hydroxy-1-cyclopentene-1-carboxamide

Compound Identifiers

PubChem CID

71655802