Brassicasterol

SKU: orb3023824

Description

Brassicasterol, as a metabolite of ergosterol, exhibits cardiovascular protective properties. This compound demonstrates antitumor effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol shows inhibitory activity against HSV-1 (IC50=1.2 μM) and Mycobacterium tuberculosis. By inhibiting sterol δ24-reductase, it delays atherosclerosis progression and has been identified as a cerebrospinal fluid biomarker for Alzheimer's disease.

Research Area

Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 474-67-9
• MW: 398.66
• Purity: 98.58%
• Formula: C₂₈H₄₆O
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](/C=C/[C@@H](C(C)C)C)C)[H])[H]
• Target: Akt,HSV,Drug Metabolite,Androgen Receptor,Antibacterial
• Solubility: Ethanol:3.7 mg/mL (9.28 mM)

Bioactivity

• Target IC50:
  HSV1:1.2μM
• In Vivo:
  Methods: Brassicasterol (100 mg/kg, intraperitoneal injection, 15 days) was used to treat HepG2.215 tumor xenograft model mice. Tumor size and mouse weight were measured every 3 days to study its therapeutic effect. Results: Brassicasterol significantly reduced tumor volume in mice without affecting their body weight.
• In Vitro:
  Methods: LNCaP cells were treated with Brassicasterol (50 μM, 48 h) to study its effects on cell cycle and apoptosis. Results: Brassicasterol was able to arrest the cell cycle of LNCaP cells at the G1 phase and induce apoptosis.

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Brassicasterol

Quick Database Links

Gene Symbol

Akt,HSV,Drug Metabolite,Androgen Receptor,Antibacterial