Boc-PEG4-Val-Cit-PAB-OH

SKU: orb3022103

Description

Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that features a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB is useful for attaching reactive groups (e.g., PNP) to bind with drug payloads. Acidic conditions can remove the Boc protecting group, exposing the primary amine for conjugation reactions to form amides. The Val-Cit-PAB segment can be cleaved by intracellular proteases, allowing efficient payload release within cells.

Key Properties

• CAS Number: 2055024-54-7
• MW: 726.858
• Formula: C₃₄H₅₈N₆O₁₁
• SMILES: N(C([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C1=CC=C(CO)C=C1
• Target: ADC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ADC Linker