Boc-NH-PEG8-CH2CH2COOH

SKU: orb1307487

Description

Boc-NH-PEG8-CH2CH2COOH is a heterobifunctional PROTAC linker featuring a Boc-protected amine and a carboxylic acid, connected by a flexible PEG spacer. This water-soluble linker is widely used in chemical biology for constructing PROTAC molecules to induce targeted protein degradation in both cellular and biochemical assays.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1334169-93-5
• MW: 541.63
• Purity: 99.64% (May vary between batches)
• Formula: C₂₄H₄₇NO₁₂
• SMILES: O(C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)C(C)(C)C
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs consist of two ligands joined by a linker: one binds to an E3 ubiquitin ligase, and the other to the target protein. This mechanism leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Alkyl/ether, BocNHPEG8CH2CH2COOH, Boc-NH-PEG-8-CH2CH2COOH, Boc-NH-PEG8-CH2CH2COOH, Boc NH PEG8 CH2CH2COOH, PROTAC Linkers, PROTAC Linker, PROTACLinker, PEGs

Compound Identifiers

PubChem CID

51341056