Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA

SKU: orb1988577

Description

This double-cleavable PEG linker is engineered for constructing antibody-drug conjugates (ADCs). Its dual-release mechanism, featuring a protease-sensitive valine-citrulline (VC) sequence and a self-immolative PAB spacer, enables targeted payload delivery in both in vitro and in vivo cancer research applications.

Research Area

Pharmacology & Drug Discovery

Key Properties

• MW: 1346.57
• Formula: C₆₆H₉₉N₁₃O₁₇
• SMILES: O=C(N1C2=CC=CC=C2C(N(CCOCCOCCOCCNC(OC(C)(C)C)=O)N=N3)=C3C4=CC=CC=C4C1)CCNC(CCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C5)=CC=C5COC(N(C)CCNC)=O)=O)=O)=O)=O
• Target: ADC Linker,PROTAC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145712365