Bobcat339 hydrochloride

SKU: orb1689025

Description

Bobcat339 hydrochloride

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2436747-44-1
• MW: 334.2
• Purity: 99.22%
• Formula: C₁₆H₁₃Cl₂N₃O
• SMILES: Cl.O=C1N=C(N)C(Cl)=CN1C2=CC=CC(=C2)C=3C=CC=CC3
• Target: DNA Methyltransferase
• Solubility: DMSO:100 mg/mL (299.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.97 mM);H2O:< 1 mg/mL (insoluble)

Bioactivity

• Target IC50:
  TET2:73 μM|TET1:33 μM
• In Vitro:
  Bobcat339 hydrochloride is a potent and selective cytosine-based TET enzyme inhibitor, which significantly reduced the overall intracellular level of 5hmC by inhibiting TET enzyme activity in HT-22 cells at a concentration of 10 μM for 24 h. The IC50 of Bobcat339 hydrochloride for TET1 and TET2 were 33 μM and 73 μM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138319672