BMS986299

SKU: orb1298014

Description

BMS986299 is a small molecule NLRP3 modulator exhibiting an EC50 of 1.28 µM. It serves as a valuable research tool for investigating NLRP3 inflammasome signaling in both cellular and animal models of inflammatory and auto-immune diseases.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2242952-69-6
• MW: 349.39
• Purity: 99.93%
• Formula: C₁₈H₁₉N₇O
• SMILES: NC=1C2=C(C=3C(=CC(=CC3)C=4C=CNN4)N1)NC(CN(C(C)=O)CC)=N2
• Target: NOD-like Receptor (NLR),NOD
• Solubility: DMSO:150 mg/mL (429.32 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.72 mM)

Bioactivity

• Target IC50:
  NLRP3:1.28 μM (EC50)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NLRP3, BMS986299, BMS-986299, BMS 986299, Unii-VS58MO4P47

Compound Identifiers

PubChem CID

137498152