BM212

SKU: orb1226228

Description

A novel antitubercular agent that possesses strong inhibitory activity against both Mycobacterium tuberculosis (MIC=0.7-1.5 ug/ml) and some nontuberculosis mycobacteria, inhibits transport activity of MmpL3; also has marked activity against several species of yeasts, including Candida albicans and Cryptococcus neoformans, is also highly efficacious against mycobacteria which show resistance to the most common traditional drugs.

Key Properties

• CAS Number: 146204-42-4
• MW: 414.3707
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₅Cl₂N₃
• SMILES: CN1CCN(CC2=C(C)N(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)=C2)CC1
• Target: Antibacterial
• Solubility: 10 mM in DMSO

Bioactivity

• In Vitro:
  BM212 (2 μg/mL and 8 μg/mL) leads to major structural changes in the cell of M. abscessus CIP104536T S and R variants and results in the complete loss of the hydrophobic nanodomains observed on S cells but no significantly affect on R cells at dose of 2 μg/mL. BM212 (0.5-10 μg/mL, 7 days) inhibits the activity of Mycobacterium avium in U937 cells in a dose-dependent manner with a MIC of 0.5 μg/mL and 100% inhibition starting at a concentration of 1 μg/mL.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BM-212 | BM 212

Quick Database Links

Gene Symbol

Antibacterial