Bis-sulfone-PEG4-NHS ester

SKU: orb3021984

Description

Bis-sulfone-PEG4-NHS ester is a bifunctional alkylating labeling reagent that selectively removes cysteine sulfur atoms from native disulfide bonds. These reagents perform bis-alkylation to attach both thiols from two cysteine residues, originating from reduced native disulfide bonds (such as interchain disulfide bonds in antibodies). The reaction results in a covalent bond through a three-carbon bridge, maintaining the protein's structural integrity. The hydrophilic PEG spacer enhances its solubility in aqueous media.

Key Properties

• CAS Number: 2055047-19-1
• MW: 844.944
• Formula: C₄₀H₄₈N₂O₁₄S₂
• SMILES: O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCNC(=O)C2=CC=C(C=C2)C(=O)C(CS(=O)(=O)C3=CC=C(C=C3)C)CS(=O)(=O)C4=CC=C(C=C4)C

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only