Biotin-PEG6-Boc

SKU: orb1307515

Description

Biotin-PEG6-Boc is a heterobifunctional PROTAC linker featuring a biotin tag for detection and a Boc-protected terminal acid. This water-soluble PEG-based spacer is utilized in constructing proteolysis-targeting chimeras for targeted protein degradation studies in both cellular and biochemical assays.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1352814-07-3
• MW: 635.81
• Purity: 98.18%
• Formula: C₂₉H₅₃N₃O₁₀S
• SMILES: C(CCCC(NCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O)=O)[C@H]1[C@@]2([C@](CS1)(NC(=O)N2)[H])[H]
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs consist of two ligands linked together, with one ligand targeting an E3 ubiquitin ligase and the other targeting the desired protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BiotinPEG6Boc, Biotin-PEG-6-Boc, Biotin-PEG6-Boc, Biotin-PEG6-t-butyl ester, Biotin PEG6 Boc, inhibit, Inhibitor, PEGs, PROTACLinker, PROTAC Linker, PROTAC Linkers

Compound Identifiers

PubChem CID

134811396