Big Gastrin - 1, human

SKU: orb2693854

Description

Big Gastrin is also referred to as Gastrin-34. Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stom ach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is gastrin-17 or little gastrin - Cat# AS-20750). Both gastrin-17 and gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.

Key Properties

• Molecular Weight: 3849.3
• Protein Sequence: {Pyr}-LGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF-NH2
• Purity: ≥95%

Storage & Handling

• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only