Bezuclastinib

SKU: orb1689060

Description

Bezuclastinib (CGT9486) is a potent and selective inhibitor targeting the tyrosine kinase c-KIT, specifically its D816V mutation implicated in advanced systemic mastocytosis. It demonstrates efficacy in both cellular assays and animal models, supporting its investigation for this and related oncologic research applications.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1616385-51-3
• MW: 331.37
• Purity: 99.81%
• Formula: C₁₉H₁₇N₅O
• SMILES: Cc1[nH]nc(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccccc2)c1C
• Target: c-Kit
• Solubility: DMSO:70 mg/mL (211.24 mM)

Bioactivity

• Target IC50:
  c-Kit (D816V):<1 μM|c-Kit:<1 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGT9486, cKit, c-Kit (D816V), PLX 9486

Compound Identifiers

PubChem CID

75593308