Betamethasone 17-valerate

SKU: orb1225661

Description

Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.(In Vivo):Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy.Betamethasone-17-valerate ointment (50 mg) inhibits homologous passive cutaneous anaphylaxis.

Key Properties

• CAS Number: 2152-44-5
• MW: 476.59
• Purity: >98% (HPLC)
• Formula: C₂₇H₃₇FO₆
• SMILES: O=C1C=C[C@@]2([C@]3([C@H](C[C@@]4([C@](OC(CCCC)=O)([C@H](C[C@]4([C@@]3(CCC2=C1)[H])[H])C)C(CO)=O)C)O)F)C
• Target: GR
• Solubility: Ethanol: 58 mg/mL (121.7 mM); DMSO: 95 mg/mL (199.33 mM)

Bioactivity

• In Vivo:
  Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy. Betamethasone-17-valerate ointment (50 mg) inhibits homologous passive cutaneous anaphylaxis. Animal model: Female Sprague-Dawley rats weighing 60-70 g (croton oil edema experiment). Dosage: 10 mg. Administration: Applied to the irritated site with a micro spatula; 5 minutes. Result: Inhibited about 50% of the ear edema without thymus atrophy.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Betamethasone Valerate | Betoid | Valison | 9α-Fluo | Valisone | Bedermin

Quick Database Links

Gene Symbol

GR