Bersiporocin

SKU: orb1984606

Description

Bersiporocin (DWN12088) is a well-tolerated, novel prolyl-tRNA synthetase (PRS) inhibitor with antifibrotic properties. It downregulates collagen synthesis, as demonstrated in cellular and animal models of idiopathic pulmonary fibrosis (IPF), where it reduced fibrosis and improved lung function.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2241808-52-4
• MW: 328.24
• Purity: 99.79% (May vary between batches)
• Formula: C₁₅H₁₉Cl₂N₃O
• SMILES: C(CC[C@@H]1[C@@H](O)CCCN1)N2C=3C(N=C2)=C(Cl)C(Cl)=CC3
• Target: DNA/RNA Synthesis
• Solubility: 10% DMSO+90% Saline:3.3 mg/mL (10.05 mM);DMSO:100 mg/mL (304.66 mM)

Bioactivity

• Target IC50:
  PRS:≤100 nM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bersiporocin, DWN12088, DWN 12088

Compound Identifiers

PubChem CID

142411678