Benzbromarone

SKU: orb1309157

Description

Benzbromarone (Desuric) is a potent and selective CYP2C9 inhibitor with a Ki of 19.3 nM. It is a valuable research tool for studying drug metabolism, enzyme kinetics, and urate transport in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 3562-84-3
• MW: 424.1
• Purity: >98%
• Formula: C₁₇H₁₂Br₂O₃
• SMILES: C(=O)(C=1C=2C(OC1CC)=CC=CC2)C3=CC(Br)=C(O)C(Br)=C3
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 20 mg/ml)

Bioactivity

• Target IC50:
  CYP2C9:19.3 nM(Ki)
• In Vivo:
  In oocytes expressing URAT1 (IC50 <0.1 μM), Benzbromarone (50 μM) completely inhibited the uptake of uric acid. In rat hepatocytes, Benzbromarone (100 μM) increased mitochondrial size and induced apoptosis in 11% of cells.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MJ10061; NSC85433

Compound Identifiers

PubChem CID

2333