Benzbromarone

SKU: orb1309157

Description

Benzbromarone (Desuric) is a potent and selective CYP2C9 inhibitor with a Ki of 19.3 nM. It is a valuable research tool for studying drug metabolism, enzyme kinetics, and urate transport in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 3562-84-3
• MW: 424.08
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₁₂Br₂O₃
• SMILES: C(=O)(C=1C=2C(OC1CC)=CC=CC2)C3=CC(Br)=C(O)C(Br)=C3
• Target: Nrf2,Bcl-2 Family,Xanthine Oxidase,HSP,NF-κB,Apoptosis,Cytochromes P450,Caspase,JNK,Interleukin
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:9 mg/mL (21.22 mM);DMSO:250 mg/mL (589.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.79 mM)

Bioactivity

• Target IC50:
  CYP2C9:19.3 nM(Ki)
• In Vivo:
  In oocytes expressing URAT1 (IC50 <0.1 μM), Benzbromarone (50 μM) completely inhibited the uptake of uric acid. In rat hepatocytes, Benzbromarone (100 μM) increased mitochondrial size and induced apoptosis in 11% of cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Normurat, Apoptosis, CYP2C9, Desuric, Benzbromarone, Xanthine Oxidase, XanthineOxidase, Urinorm

Compound Identifiers

PubChem CID

2333