Beclabuvir

SKU: orb1710295

Description

Beclabuvir

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 958002-33-0
• MW: 659.84
• Purity: 99.93%
• Formula: C₃₆H₄₅N₅O₅S
• SMILES: COc1ccc2-c3c(C4CCCCC4)c4ccc(cc4n3C[C@]3(C[C@H]3c2c1)C(=O)N1C2CCC1CN(C)C2)C(=O)NS(=O)(=O)N(C)C
• Target: HCV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.03 mM);DMSO:20 mg/mL (30.31 mM)

Bioactivity

• Target IC50:
  NS5B protein:< 28 nM
• In Vivo:
  The combination of Beclabuvir with daclatasvir and asunaprevir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1, which is the most common genotype worldwide .
• In Vitro:
  2- or 3-drug combinations of beraprevir with pegIFN/RBV and with a range of DAAs (e.g., HCV NS5A inhibitors, NS3 protease inhibitors, and/or nucleoside analog NS5B inhibitors) can show additive or synergistic antiviral activity .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NS5B protein, HCV NS5A, HCV Protease, HCVProtease, Beclabuvir, BMS791325, BMS-791325, BMS 791325

Compound Identifiers

PubChem CID

49773361