BEC hydrochloride

SKU: orb1300474

Description

BEC hydrochloride is a potent, slow-binding competitive inhibitor of arginase. It exhibits a Ki of 0.31 µM for human Arginase II and 0.4-0.6 µM for rat Arginase I. This inhibitor is widely used in both in vitro and in vivo research to study the roles of arginase in cardiovascular, pulmonary, and immunological pathways.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 222638-67-7
• MW: 229.49
• Purity: 98.65% (May vary between batches)
• Formula: C₅H₁₂BNO₄S·ClH
• SMILES: Cl.NC(CSCCB(O)O)C(O)=O
• Target: Arginase
• Solubility: DMSO:42 mg/mL (183.01 mM);H2O:41 mg/mL (178.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.71 mM);Ethanol:42 mg/mL (183.01 mM)

Bioactivity

• Target IC50:
  Arginase II:0.31 μM(Ki)
• In Vivo:
  In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure.
• In Vitro:
  BEC causes significant enhancement of NO-dependent smooth muscle relaxation. In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, inflammation, metaplasia, NF-κB, hyperresponsiveness, Arginase, Arginase-2, Arginase-II, BEC, BEC HCl, BEC Hydrochloride, BEC hydrochloride, CCL20, rat Arginase I

Compound Identifiers

PubChem CID

91976688