BD1063 dhydrochloride

SKU: orb1299776

Description

BD1063 dihydrochloride is a potent and selective sigma-1 receptor antagonist with a Ki of 9 nM. This compound is a valuable research tool for investigating the role of σ1 receptors in neurological disorders and pain, as demonstrated in various in vitro and in vivo preclinical studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 206996-13-6
• MW: 346.12
• Purity: 98.00%
• Formula: C₁₃H₂₀Cl₄N₂
• SMILES: Cl.Cl.CN1CCN(CCc2ccc(Cl)c(Cl)c2)CC1
• Target: Sigma receptor
• Solubility: H2O:50 mg/mL (144.46 mM)

Bioactivity

• In Vivo:
  BD 1063 dose-dependently reduced ethanol self-administration in sP rats (3.3–11 mg/kg) and withdrawn, dependent Wistar rats (4–11 mg/kg) at doses that did not modify mean ethanol self-administration in non-dependent Wistar controls
• Animal Research:
  Rats (controls, N=11; dependent, N=9) were pretreated with BD-1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights) using a within-subject Latin square design. sP rats: Rats (N=9) were pretreated with BD-1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis) using a within-subject Latin square design.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BD 1063, BD1063, BD-1063, BD1063 2HCL, BD1063 dhydrochloride, BD-1063 dhydrochloride, Sigmareceptor, Sigma receptor, Sigma Receptor, σ1

Compound Identifiers

PubChem CID

11617161