BCAT-IN-2

SKU: orb1694248

Description

BCAT-IN-2 is an orally bioavailable, selective inhibitor of both mitochondrial and cytosolic branched-chain aminotransferase (BCATm/BCATc). This small molecule is utilized in metabolic research, particularly for studying obesity and dyslipidemia, with applications in both in vitro enzyme assays and in vivo animal models.

Key Properties

• CAS Number: 1800024-45-6
• MW: 377.776
• Purity: 98.86% (May vary between batches)
• Formula: C₁₇H₁₄ClF₂N₅O
• SMILES: CCCc1cc(=O)n2nc(NCc3c(F)cc(Cl)cc3F)c(C#N)c2[nH]1
• Target: Others
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.29 mM);DMSO:30 mg/mL (79.41 mM)

Bioactivity

• Target IC50:
  BCAT (rat, mitochondrial):7.39 (pIC50)|BCAT (rat, cytosolic):6.6 (pIC50)
• In Vivo:
  BCAT-IN-2 (5 mg/kg, po; 1 mg/kg, iv) exhibits favorable pharmacokinetic parameters in mice.
• In Vitro:
  BCAT-IN-2 inhibits BCATm in primary human adipocytes, with a pIC50 of 6.5.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BCATIN2, BCAT-IN-2, BCAT, BCAT IN 2

Compound Identifiers

PubChem CID

78319104