BAY-8400

SKU: orb1298064

Description

BAY-8400

Research Area

Molecular Biology, Signal Transduction

Key Properties

• MW: 393.39
• Purity: 99.25% (May vary between batches)
• Formula: C₂₁H₁₇F₂N₅O
• SMILES: FC(F)C1=CN=CC(C2=CC=C(N=CC3=NN=C(C4=CCCOCC4)N35)C5=C2)=C1
• Target: DNA-PK
• Solubility: DMSO:60 mg/mL (152.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.08 mM)

Bioactivity

• Target IC50:
  DNA-PK:81 nM
• In Vivo:
  BAY-8400 (150 mg/kg; p.o.) increases the antitumor efficacy that even improved tumor-induced body weight loss. BAY-8400 shows useful aqueous solubility and oral bioavailability across species .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAY 8400, BAY8400, BAY-8400, DNA-PK, DNAPK

Compound Identifiers

PubChem CID

162366965