BAY 73-1449

SKU: orb1305181

Description

BAY 73-1449 is a highly potent and selective antagonist of the prostacyclin (IP) receptor, exhibiting an IC50 of less than 0.1 nM. This compound is a valuable research tool for investigating IP receptor function in thrombosis, inflammation, and cardiovascular disease models, both in vitro and in vivo.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 693790-96-4
• MW: 425.48
• Purity: 99.77% (May vary between batches)
• Formula: C₂₆H₂₃N₃O₃
• SMILES: OC(=O)[C@@H](Cc1ccccc1)Nc1cc(ncn1)-c1ccc(OCc2ccccc2)cc1
• Target: Others,Prostaglandin Receptor
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (5.88 mM);DMSO:55 mg/mL (129.27 mM)

Bioactivity

• Target IC50:
  Prostacyclin receptor:<0.1 nM
• In Vivo:
  In male Wistar rats, BAY 73-1449 (0.1-1 mg/kg; i.v.) significantly reduced splenic shunt vessel outflow without affecting mesenteric inflow. BAY 73-1449 (1-5 mg/kg; s.c.) has no effects on portal pressures and the degree of porto-systemic shunting in rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

lower, inhibit, inflow, outflow, Inhibitor, BAY 73 1449, BAY 731449, BAY 73-1449, BAY-73-1449, BAY73-1449, blood, prostacyclin, Prostacyclin receptor, Prostaglandin Receptor, splenic, shunt, pressure,mesenteric, portal, porto-systemic, vessel

Compound Identifiers

PubChem CID

9910289