Batimastat

SKU: orb1301154

Description

Batimastat (BB-94) is a broad-spectrum matrix metalloprotease (MMP) inhibitor. It has been utilized in research to study tumor invasion and metastasis, showing efficacy in reducing angiogenesis and tumor growth in various in vitro and in vivo experimental models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 130370-60-4
• MW: 477.64
• Purity: 98.55%
• Formula: C₂₃H₃₁N₃O₄S₂
• SMILES: CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)[C@H](CSc1cccs1)C(=O)NO
• Target: MMP
• Solubility: DMSO:50 mg/mL (104.68 mM);Ethanol:2.5 mg/mL (5.23 mM)

Bioactivity

• Target IC50:
  MMP9:4 nM|MMP2:4 nM|MMP7:6 nM|MMP1:3 nM|MMP3:20 nM
• In Vivo:
  Batimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%).Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures.
• In Vitro:
  Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MMP, MMP-7, MMP-1, MMP-3, MMP-2, MMP-9, inhibit, Inhibitor, Matrix metalloproteinases, BB94, BB-94, BB 94, Batimastat

Compound Identifiers

PubChem CID

5362422