BAM(8-22)

SKU: orb1679435

Description

This endogenous peptide, first isolated from bovine adrenal medulla, is a potent and selective MRGPRX1 agonist with EC50 values ranging from 8 to 150 nM. It lacks the met-enkephalin motif found in BAM 22P, conferring no opioid receptor affinity. This makes it a valuable tool for studying MRGPRX1's role in itch, pain, and mast cell activation in both in vitro and in vivo research models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• Target: MRGPR
• CAS Number: 412961-36-5
• MW: 1971.22
• Formula: C₉₁H₁₂₇N₂₅O₂₃S
• SMILES: C([C@@H](C(N[C@@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(NCC(O)=O)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCC(N)=O)=O)=O)CC(O)=O)=O)CCSC)=O)=O)NC([C@@H](NC(=O)[C@H]5N(C([C@@H](NC(CNC([C@H](C(C)C)N)=O)=O)CCCNC(=N)N)=O)CCC5)CCC(O)=O)=O)C=6C=7C(NC6)=CC=CC7

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

16158367