Balofloxacin

SKU: orb1226627

Description

Balofloxacin is a quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.(In Vitro):Balofloxacin (25 mg/mL; 1 h) decreases the growth of S. aureus that adhered to human corneal epithelial cells (HCECs).Balofloxacin inhibits the S. aureus ATCC 25923, with a MIC of 0.125 mg/mL.Balofloxacin (0.05-500 μg/mL; 72 h) does not induce toxicity on the HCECs at a low concentration, such as 0.625 mg/mL.(In Vivo):Balofloxacin (200 mg/kg/day; p.o. for 5 d) reduces the counts of viable M. pneumonia in the lungs of hamsters.Balofloxacin eye drops (0.5%) is effective in S. aureus bacterial keratitis of rabbits.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 127294-70-6
• MW: 389.42
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₄FN₃O₄
• SMILES: CNC1CCCN(C1)c2c(cc3c(c2OC)n(cc(c3=O)C(=O)O)C4CC4)F
• Target: DNA gyrase
• Solubility: DMSO: 5 mg/mL (12.83 mM)

Bioactivity

• In Vivo:
  Balofloxacin (200 mg/kg/day; p.o. for 5 d) reduces the counts of viable M. pneumonia in the lungs of hamsters. Balofloxacin eye drops (0.5%) is effective in S. aureus bacterial keratitis of rabbits.
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• In Vitro:
  Balofloxacin (25 mg/mL; 1 h) decreases the growth of S. aureus that adhered to human corneal epithelial cells (HCECs). Balofloxacin inhibits the S. aureus ATCC 25923, with a MIC of 0.125 mg/mL. Balofloxacin (0.05-500 μg/mL; 72 h) does not induce toxicity on the HCECs at a low concentration, such as 0.625 mg/mL.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Q-35

Quick Database Links

Gene Symbol

DNA gyrase