Balipodect

SKU: orb1307553

Description

Balipodect (TAK063) is a potent and highly selective PDE10A inhibitor with an IC50 of 0.30 nM, demonstrating over 15,000-fold selectivity against other PDE family members. This research compound is a valuable tool for investigating PDE10A function in neuropharmacology, supporting both in vitro biochemical assays and in vivo studies relevant to psychiatric disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1238697-26-1
• MW: 428.42
• Purity: 99.87% (May vary between batches)
• Formula: C₂₃H₁₇FN₆O₂
• SMILES: COc1cn(nc(-c2ccnn2-c2ccccc2)c1=O)-c1ccc(cc1F)-n1cccn1
• Target: PDE
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.67 mM);DMSO:79 mg/mL (184.4 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  PDE10A:0.3 nM
• In Vivo:
  TAK-063 has high brain penetration in mice. Oral administration of TAK-063 to mice elevated striatal cAMP and (cGMP) levels at 0.3 mg/kg and shows potent suppression of phencyclidine (PCP)-induced hyperlocomotion at a minimum effective dose (MED) of 0.3 mg/kg. TAK-063 is currently being evaluated in Clinicalal trials for the treatment of schizophrenia.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Balipodect, Inhibitor, inhibit, PDE10A, Phosphodiesterase (PDE), phosphodiesterase, TAK 063, TAK063, TAK-063

Compound Identifiers

PubChem CID

46848915