Balicatib

SKU: orb1307327

Description

Balicatib (AAE581) is a potent and selective cathepsin K inhibitor investigated for osteoporosis treatment. It has been utilized in both in vitro enzymatic assays and in vivo preclinical studies to explore its effects on bone resorption and remodeling.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 354813-19-7
• MW: 411.54
• Purity: 98.17% (May vary between batches)
• Formula: C₂₃H₃₃N₅O₂
• SMILES: CCCN1CCN(CC1)c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N
• Target: Cysteine Protease
• Solubility: DMSO:50 mg/mL (121.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.02 mM)

Bioactivity

• Target IC50:
  cathepsin L:48 nM|cathepsin K:22 nM|Cathepsin B:61 nM|cathepsin S:2900 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bone turnover, bone formation, Balicatib, AAE 581, AAE581, AAE-581, Cathepsin, Cathepsin K, dermal fibroblasts, CysteineProtease, Cysteine Protease, Inhibitor, osteoporosis, inhibit

Compound Identifiers

PubChem CID

10201696