Azido-PEG2-C6-Cl

SKU: orb1984532

Description

Azido-PEG2-C6-Cl is a polyethylene glycol (PEG)-based linker used in constructing PROTAC molecules for targeted protein degradation. This bifunctional reagent enables the conjugation of warhead ligands to E3 ubiquitin ligase binders, facilitating the development of novel degraders for in vitro and in vivo proteolysis research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2568146-55-2
• MW: 249.74
• Formula: C₁₀H₂₀ClN₃O₂
• SMILES: [N-]=[N+]=NCCOCCOCCCCCCCl
• Target: PROTAC Linker
• Solubility: DMSO:200 mg/mL (800.83 mM)

Bioactivity

• In Vitro:
  PROTACs are composed of two different ligands linked by a linker, one for the E3 ubiquitin ligase and the other for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade the target protein.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AzidoPEG2C6Cl, Azido-PEG-2-C6-Cl, Azido-PEG2-C6-Cl, Azido PEG2 C6 Cl, PROTAC Linker, PROTAC Linkers, PROTACLinker

Compound Identifiers

PubChem CID

152136129