Azide-PEG3-Desthiobiotin

SKU: orb1819333

Description

Azide-PEG3-Desthiobiotin is a polyethylene glycol (PEG)-based linker used in constructing PROTAC molecules for targeted protein degradation. This reagent is applicable in both in vitro biochemical assays and in vivo research to develop novel therapeutic strategies, leveraging its biotin moiety for purification and detection.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1426828-06-9
• MW: 414.5
• Purity: 99.27% (May vary between batches)
• Formula: C₁₈H₃₄N₆O₅
• SMILES: C(CCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)[C@@H]1[C@H](C)NC(=O)N1
• Target: Others,PROTAC Linker
• Solubility: DMSO:100 mg/mL (241.25 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.96 mM);H2O:100 mg/mL (241.25 mM)

Bioactivity

• In Vitro:
  PROTACs, comprising two distinct ligands connected by a linker—one ligand for an E3 ubiquitin ligase and the other for the target protein—exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Azide PEG3 Desthiobiotin, AzidePEG3Desthiobiotin, Azide-PEG-3-Desthiobiotin, Azide-PEG3-Desthiobiotin, PROTAC Linker

Compound Identifiers

PubChem CID

91757902