Azelnidipine

SKU: orb1310917

Description

Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker used in research to study hypertension. It is applied in both in vitro binding assays and in vivo models to investigate vascular relaxation and cardiovascular pharmacology.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 123524-52-7
• MW: 582.65
• Purity: 99.28% (May vary between batches)
• Formula: C₃₃H₃₄N₄O₆
• SMILES: O=C(C1=C(N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2)OC3CN(C3)C(C4=CC=CC=C4)C5=CC=CC=C5
• Target: MEK,Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.87 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:7 mg/mL (12.01 mM);DMSO:108 mg/mL (185.36 mM)

Bioactivity

• In Vivo:
  Studies indicate that Azelnidipine, as a new-generation calcium channel blocker, can treat hypertension regardless of the patient's risk for ischemic heart disease. This novel, long-acting calcium channel blocker exhibits unique pharmacological properties, such as a slower heart rate and high affinity for vascular tissue, distinguishing it from other calcium channel blockers. Additionally, the high lipophilicity of Azelnidipine allows it to remain active in the vascular wall even after being cleared from the bloodstream.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, CS 905, CS905, CS-905, Calcium Channel, CalciumChannel, Ca2+ channels, Ca channels, Azelnidipine, UR12592, UR-12592, UR 12592

Compound Identifiers

PubChem CID

65948