AzddMeC

SKU: orb1701118

Description

AzddMeC

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 87190-79-2
• MW: 266.26
• Purity: 97.14% (May vary between batches)
• Formula: C₁₀H₁₄N₆O₃
• SMILES: Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)nc1N
• Target: Reverse Transcriptase,Nucleoside Antimetabolite/Analog,HIV Protease
• Solubility: DMSO:100 mg/mL (375.57 mM)

Bioactivity

• Target IC50:
  HIV-1:6 nM (EC50, Human macrophages)|HIV-1:9 nM (EC50, Human PBM cells)
• In Vivo:
  Following intravenously and orally administered 60 mg/kg AzddMeC to male rhesus monkeys, 3'-azido-3'-deoxythymidine (AZT) was found to be the major metabolite of AzddMeC in monkeys. Serum concentrations of AzddMeC decreased rapidly in a biexponential manner with terminal half-lives ranging from 0.5 to 1.3 h. Total clearance of AzddMeC was 2.00 +/- 0.41 l/h/kg (mean +/- standard deviation) and the fraction of AzddMeC metabolized to AZT was 0.32 +/- 0.05. The total clearance was 2.00 +/- 0.41 l/h/kg (mean +/- standard deviation).
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• In Vitro:
  AzddMeC emerged as the most potent inhibitor of hepatitis B virus DNA polymerase (50% inhibitor dose, 0.03-0.35 μM). In contrast, cellular DNA polymerase was shown to be resistant to or partially (β) affected by AzddMeC.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Az-Dcme, AzddMeC, Azidodideoxymethylcytidine, CS92, CS-92, CS 92, HIV Protease, HIV-1, HIVProtease

Compound Identifiers

PubChem CID

64986