AZD9567

SKU: orb1707605

Description

AZD9567 is a potent, selective, and orally bioavailable non-steroidal glucocorticoid receptor modulator (SGRM) with an IC50 of 3.8 nM. It has shown significant anti-inflammatory efficacy in vivo, such as in the SCW-induced joint reactivation model, supporting its research use in inflammation and autoimmune disease studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1893415-00-3
• MW: 494.53
• Purity: 98.77%
• Formula: C₂₇H₂₈F₂N₄O₃
• SMILES: CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccccc1
• Target: Glucocorticoid Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (5.06 mM);DMSO:50 mg/mL (101.11 mM)

Bioactivity

• Target IC50:
  GR:3.8 nM
• In Vivo:
  AZD9567 (15 mg/kg/day; Oral gavage; daily for 8 days; female Lewis rats; sensitized by intra-articular injection of 5 μg of SCW) inhibited ankle swelling in the rat SCW model. The treatment shows excellent in vivo efficacy in a rat model of joint inflammation.

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GlucocorticoidReceptor, Glucocorticoid Receptor, Glucocorticoid receptor, Mizacorat, AZD-9567, AZD9567, AZD 9567

Compound Identifiers

PubChem CID

121248172